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Lack of a direct role for cyclic AMP in parathyrin action on phosphate reabsorption by the kidney
Author(s) -
Parveen Riffat,
Grahn Michael F.,
Butterworth Peter J.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80945-x
Subject(s) - reabsorption , phosphate , endocrinology , chemistry , medicine , kidney , action (physics) , biochemistry , physics , quantum mechanics
Isolated chick kidney proximal tubule cells have been used in a study of the mechanism by which PTH inhibits Na + ‐dependent P i transport in the kidney. Treatment with PTH inhibits P i uptake by the cells by 13% and stimulates cyclic AMP production by 77%. Forskolin, a potent activator of adenyl cyclase, brought about an 11‐fold stimulation of cyclic AMP production by the cells, but in contrast to PTH, the drug had no effect on Na + ‐dependent P i uptake. These results provide evidence that PTH action on phosphate transport is not mediated by cyclic AMP.