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Anti‐LPS factor in the horseshoe crab, Tachypleus tridentatus
Author(s) -
Ohashi Kunihiro,
Niwa Makoto,
Nakamura Takanori,
Morita Takashi,
Iwanaga Sadaaki
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80942-4
Subject(s) - horseshoe crab , hemolysis , lysis , biology , microbiology and biotechnology , coagulation , chemistry , zoology , biochemistry , immunology , ecology , medicine
Anti‐LPS factor, which inhibits the endotoxin mediated coagulation system in the horseshoe crab, Tachypleus tridentatus , was found to lyse red blood cells sensitized with gram‐negative bacterial LPS, but not to lyse unsensitized cells. This hemolysis occurred even at 0°C and was completed within 1 min. The binding of anti‐LPS factor to LPS must be essential for the hemolysis, because free LPS inhibited the hemolytic action of anti‐LPS factor.