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Inositol 1,4,5‐trisphosphate may be a signal for f‐Met‐Leu‐Phe‐induced intracellular Ca mobilisation in human leucocytes (HL‐60 cells)
Author(s) -
Burgess Gillian M.,
McKinney Jerry S.,
Irvine Robin F.,
Berridge Michael J.,
Hoyle Peter C.,
Putney James W.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80939-4
Subject(s) - inositol , endoplasmic reticulum , inositol trisphosphate receptor , intracellular , agonist , chemistry , receptor , inositol phosphate , biochemistry , microbiology and biotechnology , inositol trisphosphate , biology
Pemeabilised, dimethyl sulphoxide‐differentiated HL‐60 human myelomonocytic leukemia cells accumulate 45 Ca in an ATP‐dependent manner. The 45 Ca is taken up by a pool thought to be a component of the endoplasmic reticulum. Inositol trisphosphate induced a rapid release of Ca from this pool, suggesting that this molecule which is formed in these cells in response to f‐Met‐Leu‐Phe may play a role in agonist‐induced Ca metabolism.