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Degradation of soluble collagen by ozone or hydroxyl radicals
Author(s) -
Curran Samantha F.,
Amoruso Marie A.,
Goldstein Bernard D.,
Berg Richard A.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80931-x
Subject(s) - radical , degradation (telecommunications) , chemistry , ozone , hydroxyl radical , photochemistry , environmental chemistry , biochemistry , organic chemistry , telecommunications , computer science
Collagen exposed to ozone or hydroxyl radicals was degraded in a time‐ and dose‐dependent manner. This degradation was inhibited by free radical scavengers. Furthermore, lower levels of these oxidants did not degrade the molecule, but caused it to become susceptible to proteolytic degradation. We suggest an alternative mechanism by which oxygen‐derived free radicals participate in the destruction of extracellular matrix observed during acute lung injury by oxidant gas, in addition to the commonly accepted proteinase‐antiproteinase theory of lung injury.