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Transfer of ferritin‐bound iron to adriamycin
Author(s) -
Demant Erland J.F.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80919-9
Subject(s) - ferritin , chemistry , submitochondrial particle , incubation , intracellular , lipid peroxidation , biochemistry , biophysics , mitochondrion , biology , oxidative stress
Interactions of adriamycin with ferritin‐bound iron have been investigated. It is demonstrated (i) that adriamycin stimulates an iron‐dependent lipid peroxidation in submitochondrial particles in the presence of ferritin, and (ii) that incubation of adriamycin with ferritin results in a slow transfer of iron to adriamycin with formation of an adriamycin‐iron complex. The results are discussed in relation to the possible role for intracellular iron in adriamycin toxicity.