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Specific inhibition of human β‐D‐glucuronidase and α‐L‐iduronidase by a trihydroxy pipecolic acid of plant origin
Author(s) -
di Bello Isabelle Cenci,
Dorling Peter,
Fellows Linda,
Winchester Bryan
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80911-4
Subject(s) - glucuronidase , beta glucuronidase , microsome , biochemistry , chemistry , enzyme , glucuronic acid , glucuronates , glucosidases , human liver , polysaccharide , gene expression , gene
The glucuronic acid analogue of 1‐deoxynojirimycin, 2( S )‐carboxy‐3( R ), 4( R ), 5( S )‐trihydroxypiperidine, recently isolated from seeds of Baphia racemosa , is a novel specific inhibitor of human liver β‐D‐glucuronidase and α‐L‐iduronidase. No other glycosidases are inhibited. The inhibition of β‐D‐glucuronidase is competitive, with a K i of 8 × 10 −5 M and is pH‐dependent. This inhibitor may be useful to induce a mucopolysaccharidosis or to investigate the function of microsomal β‐D‐glucoronidase.