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The L7/L12 proteins change their conformation upon interaction of EF‐G with ribosomes
Author(s) -
Gudkov A.T.,
Gongadze G.M.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80906-0
Subject(s) - ribosome , chemistry , biophysics , crystallography , biochemistry , biology , rna , gene
The different functional complexes of ribosomes with elongation factor F (EF‐G) were studied by digestion experiments with trypsin. It was found that upon interaction of EF‐G with ribosomes the L7/L12 proteins are sensitive to trypsin and are trypsin resistant after dissociation of EF‐G from ribosomes. The significance of conformational alterations in the L7/L12 and also in the other proteins in the translation process is discussed.