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Reduced maximum capacity of glycolysis in brown adipose tissue of genetically obese, diabetic (db/db) mice and its restoration following treatment with a thermogenic β‐adrenoceptor agonist
Author(s) -
Young P.,
Cawthorne M.A.,
Levy Alison L.,
Wilson Karen
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80903-5
Subject(s) - endocrinology , phosphofructokinase , medicine , brown adipose tissue , adipose tissue , hexokinase , agonist , glycolysis , chemistry , white adipose tissue , biology , receptor , metabolism
The maximal activities of the key glycolytic enzymes hexokinase and 6‐phosphofructokinase, were reduced in brown adipose tissue in db/db mice compared to their lean littermates. Treatment of db/db mice with the thermogenic β‐adrenoceptor agonist, BRL 26830, restored normoglycaemia. The only significant increase in activity of hexokinase and 6‐phosphofructokinase in the BRL 26830‐treated db/db mice occurred in brown adipose tissue where the total tissue activity increased 10‐ and 11‐fold respectively. These changes together with increased 2‐deoxyglucose uptake in vivo suggest that brown adipose tissue can play a quantitatively important role in the removal of glucose from the blood.