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Comparative changes of levels of nitrendipine Ca 2+ channels, of tetrodotoxin‐sensitive Na + channels and of ouabain‐sensitive (Na + + K + )‐ATPase following denervation of rat and chick skeletal muscle
Author(s) -
Schmid Annie,
Kazazoglou Theodossia,
Renaud Jean-François,
Lazdunski Michel
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80885-6
Subject(s) - ouabain , chemistry , tetrodotoxin , nitrendipine , biophysics , sodium , calcium , biology , organic chemistry
Three major ion transport systems, the nitrendipine‐sensitive Ca 2+ channels, the tetrodotoxin‐sensitive Na + channel and the ouabain‐sensitive (Na + + K + ‐ATPase, have been studied in skeletal muscle from rat and chick after chronic denervation. It is shown that the situation found for the Ca 2+ channel differs dramatically from that found for the Na 2+ channel and the (Na 2+ + K + )‐ATPase and that regulation of the nitrendipine‐sensitive Ca 2+ channel in denervated muscle also differs widely from that of the tetrodotoxinsensitive Na + channel and the ouabain‐sensitive (Na + + K + ‐ATPase which show a quite similar evolution.