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Dantrolene does not block calcium pulse‐induced calcium release from a putative calcium channel in sarcoplasmic reticulum from malignant hyperthermia and normal pig muscle
Author(s) -
Nelson T.E.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80845-5
Subject(s) - malignant hyperthermia , calcium , dantrolene , dantrolene sodium , chemistry , ryanodine receptor , skeletal muscle , hyperthermia , endocrinology , biophysics , endoplasmic reticulum , calcium channel , voltage dependent calcium channel , medicine , t type calcium channel , calcium atpase , biochemistry , anesthesia , biology , atpase , enzyme , organic chemistry
Calcium pulse additions to isolated SR membranes can cause a reversible efflux of calcium. The threshold level of calcium loading at which calcium efflux occurs is lower for SR membranes isolated from malignant hyperthermia susceptible (MHS) swine. Dantrolene, a unique muscle relaxant, had no effect on threshold calcium load, amounts and rates of calcium release from SR isolated from control and MHS skeletal muscle. It is concluded that the putative calcium channel through which this calcium pulse‐induced calcium release mechanism occurs is not affected by dantrolene under these experimental conditions.