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The organ uptake of intravenously administered colloidal particles can be altered using a non‐ionic surfactant (Poloxamer 338)
Author(s) -
Illum L.,
Davis S.S.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80836-4
Subject(s) - poloxamer , pulmonary surfactant , mononuclear phagocyte system , poloxamer 407 , colloid , chemistry , adsorption , polystyrene , ionic bonding , chemical engineering , particle (ecology) , biophysics , chromatography , biochemistry , copolymer , organic chemistry , medicine , pathology , polymer , ion , biology , ecology , engineering
Small polystyrene particles coated with a high M r non‐ionic surfactant (Poloxamer 338) are diverted from the reticuloendothelial system of the liver and spleen to other tissue sites. These results are discussed in terms of the adsorption of the Poloxamer to the particle surface and the implications for drug targeting.