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Mitomycin C‐induced deoxyribose degradation inhibited by superoxide dismutase
Author(s) -
Gutteridge John M.C.,
Quinlan Gregory J.,
Wilkins Stephanie
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80828-5
Subject(s) - deoxyribose , chemistry , superoxide dismutase , catalase , mitomycin c , hydroxyl radical , reactive oxygen species , semiquinone , thiobarbituric acid , biochemistry , radical , superoxide , medicinal chemistry , antioxidant , enzyme , lipid peroxidation , quinone , surgery , medicine , dna
Mitomycin C stimulates deoxyribose degradation with the release of thiobarbituric acid‐reactive material under conditions of low oxygen concentration. This damage is inhibited by scavengers of the hydroxyl radical, iron chelators and the specific proteins catalase and superoxide dismutase. The reactive radical species appears to arise from a Fenton‐type sequence in which iron is reduced by the mitomycin C semiquinone radical.