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Effects of analogues of adenosine and methyl xanthines on insulin sensitivity in soleus muscle of the rat
Author(s) -
Budohoski Leszek,
John Challis R.A.,
McManus Bronwyn,
Newsholme Eric A.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80820-0
Subject(s) - adenosine , insulin , medicine , adenosine deaminase , chemistry , endocrinology , soleus muscle , xanthine , stimulation , glycolysis , skeletal muscle , metabolism , biochemistry , biology , enzyme
The concentration of insulin that produces half‐maximal stimulation of glycolysis by stripped soleus muscle preparations is markedly increased by the adenosine analogues, 2‐chloroadenosine and N 6 ‐phenylisopropyladenosine, but is markedly decreased by the methyl xanthine analogue, 8‐phenyltheophylline. 2‐Chloroadenosine increases the concentration of insulin required to stimulate glycolysis half maximally, from about 100 to 2000 μunits/ml. 8‐Phenyltheophylline decreases this concentration of insulin from about 100 to 10 μunits/ml, an effect which is similar to that produced either by addition of adenosine deaminase to the medium or to exercise‐training of the donor animals for 4 weeks.