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Increased insulin sensitivity in soleus muscle from cold‐exposed rats: reversal by an adenosine‐receptor agonist
Author(s) -
Budohoski Leszek,
Challiss R.A.John,
Lozeman Fred J.,
McManus Bronwyn,
Newsholme Eric A.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80777-2
Subject(s) - medicine , endocrinology , adenosine , agonist , soleus muscle , chemistry , insulin , glycogen , receptor , adenosine receptor , skeletal muscle , biology
The effect of 0.5,2,7 and 14 days cold exposure at 4°C on insulin sensitivity was investigated in the stripped soleus muscle preparation incubated in vitro. Cold‐exposure for 2 or 7 days increased the sensitivity of glycolysis, but did not affect the sensitivity of glycogen synthesis to insulin. Cold‐exposure for 0.5 or 14 days had no effect on the sensitivity of either process to insulin. The increased sensitivity to insulin after exposure of animals to the cold for 2 days was completely reversed by addition of the adenosine receptor agonist, 2‐chloroadenosine, to the incubation medium. This suggests that cold exposure may increase insulin sensitivity in the muscle, either by a decrease in the concentration of adenosine in the muscle, or by a decrease in the number or affinity of the adenosine receptors.