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Blood group H antigen with globo‐series structure
Author(s) -
Kannagi Reiji,
Levery Steven B.,
Hakomori Sen-itiroh
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80776-0
Subject(s) - antigen , monoclonal antibody , chemistry , alpha (finance) , mass spectrometry , blood group antigens , nuclear magnetic resonance spectroscopy , antibody , microbiology and biotechnology , stereochemistry , biology , immunology , chromatography , medicine , construct validity , nursing , patient satisfaction
Blood group H antigen with globo‐series structure, reacting with the monoclonal antibody MBrl, was isolated and characterized from human blood group O erythrocytes. The structure was identified by methylation analysis, direct probe mass spectrometry, and 1 H‐nuclear magnetic resonance spectroscopy as shown below: Fucαl → 2Galβl → 3GalNAcβl → 3Galαl → 4Galβl → 4Glcβl → 1Cer