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The effect of phalloidin on insulin secretion from islets of langerhans isolated from rat pancreas
Author(s) -
Stutchfield Jane,
Howell Simon L.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80775-9
Subject(s) - phalloidin , islet , microfilament , secretion , actin , insulin , pancreas , medicine , endocrinology , chemistry , microbiology and biotechnology , biology , cytoskeleton , cell , biochemistry
Phalloidin, which stabilizes F‐actin, has no effect on insulin secretion from intact islets, but penetrates and increases secretion from islets previously made permeable using a high voltage discharge technique. Use of this highly specific drug strongly suggests a role for microfilaments composed of F‐actin in the insulin secretory process.