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Modelling the ATP‐binding site of oncogene products, the epidermal growth factor receptor and related proteins
Author(s) -
Sternberg Michael J.E.,
Taylor William R.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80774-7
Subject(s) - epidermal growth factor receptor , binding site , epidermal growth factor , biology , microbiology and biotechnology , biochemistry , chemistry , receptor
A three‐dimensional model for the ATP‐binding site of the oncogene product v‐src is proposed by the use of interactive computer graphics. A similar model would apply to sequence related proteins such as other oncogene products, the epidermal growth factor receptor, cAMP‐dependent protein kinase and the cell division control protein CDC28. The model was proposed on the basis of the conservation of certain key residues between the oncogene product family of proteins and several nucleotide binding proteins of known structures.