Premium
Metabolite‐mediated catalyst conversion of PFK and PFP: can PFK really be converted to PFP?
Author(s) -
Gancedo Juana M.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80770-x
Subject(s) - pyrophosphate , phosphofructokinase , chemistry , biochemistry , enzyme , fructose , fructose 1,6 bisphosphatase , metabolite , glycolysis
It has been suggested that in spinach leaves an enzyme able to catalyze the phosphorylation of fructose 6‐phosphate to fructose 1,6‐bisphosphate can exist in two different interconvertible forms which use ATP and pyrophosphate respectively as phosphoryl donors [FEBS Letters 169 (1984) 287‐292]. However, the data presented to support this suggestion could also be interpreted without assuming such an unusual type of interconversion. This reinterpretation considers that PFK and PFP are two distinct enzymes which are differentially activated by incubation with various effectors such as UDPG, pyrophosphate, ATP, fructose 6‐phosphate and fructose 2,6‐bisphosphate.