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The location of antigenic sites on ferritin molecules
Author(s) -
Addison Janet M.,
Treffry Amyra,
Harrison Pauline M.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80763-2
Subject(s) - cleavage (geology) , antigen , chemistry , ferritin , protein primary structure , epitope , amino acid , biochemistry , molecule , biology , microbiology and biotechnology , peptide sequence , genetics , gene , paleontology , organic chemistry , fracture (geology)
Immunoreactivities of peptides purified after cleavage of human liver apoferritin are reported and discussed in relation to the known 3‐dimensional and primary structures of homologous apoferritins. These studies point to 3 antigenic sites occupying continuous inter‐helical regions of the polypeptide chains which lie on the surface of the apoferritin molecule. Other antigenic regions may encompass amino acids remote in the primary structure or belonging to different subunits.