Premium
GTP interacts with the γ‐subunit of eukaryotic initiation factor eIF‐2
Author(s) -
Kurzchalia T.V.,
Bommer U.-A.,
Babkina G.T.,
Karpova G.G.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80758-9
Subject(s) - gtp' , protein subunit , initiation factor , eif2 , eukaryotic initiation factor , chemistry , transfer rna , biochemistry , microbiology and biotechnology , biology , ribosome , rna , enzyme , gene
Eukaryotic initiation factor eIF‐2 is an oligomeric protein consisting of three different subunits. During initiation of protein synthesis eIF‐2 interacts with GTP, Met‐tRNA f and 40 S ribosomal subunit. By affinity labeling with a photo‐reactive GTP analogue it was shown that in the binary complex [eIF‐2 · GTP] GTP is in contact with the γ‐subunit of eIF‐2.