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Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions
Author(s) -
Capdevila J.,
Snijder G.D.,
Falck J.R.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80625-0
Subject(s) - arachidonic acid , microsome , epoxygenase , anterior pituitary , chemistry , biochemistry , microsoma , arachidonic acid metabolism , medicine , chromatography , endocrinology , biology , enzyme , hormone
Microsomal fractions isolated from rat anterior pituitary glands catalyze the oxygenation of arachidonic acid. By a combination of Chromatographic and mass spectrometric techniques, we have identified epoxy‐eicosatrienoic acids as reaction products and thus documented the presence of an NADPH‐dependent arachidonic acid epoxygenase activity in rat adenohypophysis.