Premium
Activation of yeast 6‐phosphofructo‐2‐kinase by protein kinase and phosphate
Author(s) -
Yamashoji Shiro,
Hess Benno
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80611-0
Subject(s) - yeast , protein kinase a , chemistry , mitogen activated protein kinase kinase , kinase , biochemistry , microbiology and biotechnology , biology
6‐phosphofructo‐2‐kinase (PFK2) is activated by a cAMP‐dependent protein kinase, and inactivated by phosphatase, indicating the interconversion of PFK2. Inorganic phosphate also activates PFK2, and the optimum pH for the PFK2 activity varies with the concentration of phosphate. Phosphate also enhances the inactivation of PFK2 by citrate, suggesting that phosphate acts as a regulator of PFK2.