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The H + /O ratio of proton translocation linked to the oxidation of succinate by mitochondria
Author(s) -
Krab Klaas,
Soos Jozsef,
Wikström Mårten
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80598-0
Subject(s) - mitochondrion , proton , chemistry , biophysics , biochemistry , physics , biology , nuclear physics
In a recent communication Lehninger and co‐workers (Costa L.E., Reynaferje B., and Lehninger A.L. (1984) J. Biol. Chem. 259, 4802‐4811) reported values approaching 8 for the H + /O ratio of vectorial proton ejection from rat liver mitochondria respiring with succinate. Here we present a rigorous analysis of these measurements which reveals that they may significantly overestimate the true H + /O stoicheiometry.