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Synergism between phorbol ester and A23187 in Superoxide production by neutrophils
Author(s) -
Dale M.Maureen,
Penfield Adrienne
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80592-x
Subject(s) - superoxide , protein kinase c , calcium , phorbol , respiratory burst , chemistry , ionophore , phorbol ester , cytosol , biochemistry , kinase , enzyme , organic chemistry
Concentrations of phorbol myristate acetate and the calcium ionophore, A23187, which by themselves are minimally effective in stimulating Superoxide generation in human neutrophils show marked mutual potentiation when given together. This supports the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in the stimulus/activation coupling of the respiratory burst in the neutrophil. Neutrophil Phorbol ester Protein kinase C Calcium