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Relationships between the effects of redox potential, α‐Thenoyltrifluoroacetone and malonate on O 2 − and H 2 O 2 generation by submitochondrial particles in the presence of succinate and antimycin
Author(s) -
Ksenzenko Marina,
Konstantinov Alexander A.,
Khomutov Gennadiy B.,
Tikhonov Alexander N.,
Ruuge E.K.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80579-7
Subject(s) - thenoyltrifluoroacetone , submitochondrial particle , chemistry , redox , malonate , radiochemistry , inorganic chemistry , biochemistry , mitochondrion , organic chemistry , extraction (chemistry) , solvent extraction
The rate of the antimycin‐induced H 2 O 2 and O 2 XXX generation in beef heart submitochondrial particles is maximal at the [succinate]/[fumarate] ratio of 1:5 and decays at both higher and lower redox potentials. Succinate dehydrogenase inhibitors, such as TTFA or malonate, stimulate active oxygen production in the presence of excess succinate but are inhibitory at E h , values more positive than the optimal. The modulation of O 2 xxx and H 2 O 2 generation by these inhibitors can be explained by their effects on the steady‐state redox potential(s) of the component(s) of mitochondrial site 2.