Premium
Cytochrome b reduction by hexaammineruthenium in mitochondria and submitochondrial particles
Author(s) -
Kunz Wolfram S.,
Konstantinov Alexander
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80578-5
Subject(s) - submitochondrial particle , redox , chemistry , antimycin a , cytochrome , cytochrome b , mitochondrion , cytochrome c1 , cytochrome c , biochemistry , coenzyme q – cytochrome c reductase , biophysics , stereochemistry , biology , organic chemistry , enzyme , mitochondrial dna , gene
In the presence of ascorbate, hexaamineruthenium mediates rapid reduction of cytochrome b ‐562 in submitochondrial particles but not in mitochondria. The reaction is obsreved in the combined presence of antimycin (or funiculosin) and myxothiazol, which implies direct interaction of Ru(NH 3 ) 2+ 6 with b cytochrome(s). We assume that contrary to previous conclusions (Case and Leigh (1976) Biochem. J., 160, 769‐783) redox centre of at least one of the oxidized cytochromes b , most probably of b ‐562, is exposed to the M‐aqueous phase.