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The Ca 2+ /Cl − dependent L‐[ 3 H]glutamate binding: a new receptor or a particular transport process?
Author(s) -
Pin J.-P.,
Bockaert J.,
Recasesn M.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80563-3
Subject(s) - glutamate receptor , chemistry , biophysics , membrane , receptor , binding site , biochemistry , biology
Ca 2+ /Cl − increases the L‐[ 3 H]glutamate binding to rat brain synaptic membranes. It was suggested that Ca 2+ /Cl − expresses a new class of glutamate receptors. We report several lines of evidence suggesting that Ca 2+ /Cl − in fact favours a glutamate transport into membrane vesicles. This finding may serve to reconcile most of the discrepancies found in the literature on the glutamate binding and its pharmacology.