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The complete amino‐acid sequence of anglerfish somatostatin‐28 II
Author(s) -
Morel Alain,
Chang Jui-Yoa,
Cohen Paul
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80561-x
Subject(s) - somatostatin , chemistry , sequence (biology) , biochemistry , biology , endocrinology
A new somatostatin‐28 has been isolated from the Teleostean fish ( Lophius piscatorius ) Brockmann organs. Determination of its aminoacid sequence indicates that it corresponds to an octacosapeptide containing in its C‐terminal end the Tyr‐7 Gly‐10 derivative of somatostatin‐14 I. This structure is in agreement with the one predicted by Hobart et al. (Nature (1980) 288, 137‐141) from a cDNA nucleotide sequence. It demonstrates that, since the corresponding somatostatin‐14 II cannot be detected in this organ, S‐28 II is a terminal product of prosomatostatin II processing in anglerfish pancreatic islets.