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Studies on the substrate for hepatic lipogenesis in the rat
Author(s) -
Geelen Math J.H.,
Hindriks Georg A.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80558-x
Subject(s) - lipogenesis , glycogen , substrate (aquarium) , glycogen synthase , biochemistry , chemistry , carbohydrate , medicine , endocrinology , liver metabolism , biology , metabolism , ecology
The contribution of hepatic glycogen to lipogenesis was studied in isolated, intact rat hepatocytes. To establish its importance as a substrate for lipogenesis, the glycogen of isolated hepatocytes was prelabelled with 14 C from glucose. Evidence is presented that neither glucose nor glycogen constitute major sources of carbon for de novo synthesis of fatty acids and that less than 1 % of glycogen is converted into fatty acids.