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Identification of M r variants of proclatin with monoclonal antibodies
Author(s) -
Aston R.,
Young K.,
van den Berg H.,
Ivanyi J.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80486-x
Subject(s) - monoclonal antibody , amniotic fluid , prolactin , antibody , molecular mass , hormone , microbiology and biotechnology , biology , monoclonal , function (biology) , chemistry , biochemistry , endocrinology , immunology , pregnancy , genetics , fetus , enzyme
Monoclonal antibodies (QB01 and 1200) prepared against human proclatin (hPRL) have helped define a variant form of the hormone. This variant is of apparently higher molecular mass (26kDa) than the predominant form of the hormone (24kDa) and its presence does not appear to be species‐restricted. The demonstration of the 26 kDa form of the hPRL in fresh pituitary tissue and amniotic fluid suggests it may retain some specific function.