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The mechanisms of the cyclic AMP‐dependent regulation of the enzymes of the 2′,5′‐oligoadenylate system
Author(s) -
Itkes A.V.,
Turpaev K.T.,
Kartasheva O.N.,
Tunitskaya V.L.,
Kafiani C.A.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80467-6
Subject(s) - enzyme , phosphodiesterase , pde10a , protein kinase a , chemistry , microbiology and biotechnology , phosphodiesterase 3 , enzyme activator , biochemistry , biology
The cAMP‐dependent induction of 2,5‐oligoadenylate (2‐5A) synthetase and cAMP‐dependent inhibition of 2‐5A phosphodiesterase are shown. Variations in activities of cAMP‐dependent protein kinase and the enzymes of 2‐5A metabolism in the cells deepening into the resting state were found to be compatible with the above finding. A scheme of coordinated action of cAMP and 2‐5A is proposed.