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Base‐specific ribonucleases potentially involved in heterogeneous nuclear RNA processing and poly(A) metabolism
Author(s) -
Bachmann Michael,
Schröder Heinz C.,
Messer Rudolf,
Müller Werner E.G.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80453-6
Subject(s) - endoribonuclease , exoribonuclease , polyadenylation , snrnp , rna , nuclease , rna splicing , messenger rna , biology , small nuclear ribonucleoprotein , biochemistry , ribonucleoprotein , chemistry , microbiology and biotechnology , enzyme , rnase p , gene
Polyadenylation and splicing of heterogeneous nuclear RNA, two crucial steps in mRNA processing, are apparently enzymically mediated processes. This contribution summarizes the properties and the presumed functions of the known poly(A) catabolic enzymes (endoribonuclease IV and V, 2′,3′‐exoribonuclease) as well as those of the pyrimidine‐specific endoribonucleases associated with snRNP—hnRNP complexes (endoribonuclease VII, acidic p I 4.1 endoribonuclease and poly(U)‐specific U1 snRNP‐nuclease).