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Fructose 2,6‐biphosphate, sugar phosphates and adenine nucleotides in the regulation of glucose metabolism in the lactating rat mammary gland
Author(s) -
Sochor Milena,
Greenbaum A.L.,
McLean Patricia
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80279-3
Subject(s) - fructose , carbohydrate metabolism , sugar , nucleotide , biochemistry , chemistry , sugar phosphates , glycolysis , adenine nucleotide , metabolism , nucleotide sugar , fructose 2,6 bisphosphate , mammary gland , endocrinology , medicine , biology , enzyme , phosphofructokinase , cancer , breast cancer , gene
Fructose 2,6‐bisphosphate is present in the rat mammary gland, rising from a value of 1.4 nmol/g in pregnancy to 4.3 nmol/g tissue at 14 days lactation; the equivalent values calculated/ml intracellular water are 5.2 and 11.6 nmol, respectively. The tissue content of fructose 6‐phosphate, fructose 1,6‐bisphosphate, ATP and phospho enol pyruvate remain relatively constant in the transition from pregnancy to the height of lactation. The changes in AMP, cyclic AMP, and citrate content of the mammary gland during lactation are such as to promote an increase in frutose 2,6‐bisphosphate formation and flux through phosphofructokinase.