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Different adhesion inhibiting activities of antisera against plasma membranes of liver and Morris hepatoma 7777
Author(s) -
Neumeier Reinhard,
Dethlefs Ulrike,
Reutter Werner
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80254-9
Subject(s) - antiserum , adhesion , membrane , cell adhesion molecule , chemistry , cell adhesion , neural cell adhesion molecule , microbiology and biotechnology , biochemistry , antibody , biology , immunology , organic chemistry
Cell‐substratum adhesion of rat hepatocytes was inhibited by antisera raised against plasma membranes of liver (anti‐liver antiserum) and Morris hepatoma 7777 (anti‐hepatoma antiserum). Similar concentrations of both antisera inhibited adhesion on collagen. Anti‐liver antiserum also inhibited the adhesion of hepatocytes on plastic, whereas anti‐hepatoma antiserum was only able to inhibit the adhesion on collagen completely. These results suggest the existence of at least two different adhesion‐involved molecules. Cells adhere to plastic by means of both molecules, whereas adhesion on collagen is mediated by only one of them. The results further suggest that hepatoma cells lost the molecule involved in adhesion on plastic.