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Increase in cytosolic Ca 2+ concentration during t ‐butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca 2+ stores
Author(s) -
Bellomo Giorgio,
Thor Hjördis,
Orrenius Sten
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80202-1
Subject(s) - cytosol , intracellular , metabolism , chemistry , biochemistry , biophysics , enzyme , biology
Activation of phosphorylase a in hepatocytes incubated with t ‐butyl hydroperoxide indicates that hydroperoxide metabolism is associated with an increase in cytosolic free Ca 2+ concentration which appears to be mediated by NADPH oxidation and to involve mobilization of intracellular Ca 2+ stores.