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CAPP‐calmodulin: A potent competitive inhibitor of calmodulin actions
Author(s) -
Newton Dianne L.,
Klee Claude B.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80183-0
Subject(s) - calmodulin , calcineurin , chemistry , antagonist , biochemistry , phosphodiesterase , enzyme , receptor , medicine , transplantation
A covalent adduct of norchlorpromazine (CAPP) and calmodulin is a very potent antagonist of calmodulin activation of several enzymes. The phenothiazine‐calmodulin complex (CAPP‐calmodulin) acts as a pure antagonist with phosphodiesterase and myosin kinase or a partial agonist with the phosphoprotein phosphatase, calcineurin. Because of its potency and the selectivity inherent to its calmodulin moiety, CAPP‐calmodulin should be a uniquely useful probe of calmodulin actions.