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New potent inhibitors of angiotensin converting enzyme
Author(s) -
Attwood Michael R.,
Francis R.John,
Hassall Cedric H.,
Kröhn Antonin,
Lawton Geoffrey,
Natoff Ian L.,
Nixon John S.,
Redshaw Sally,
Thomas W.Anthony
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80169-6
Subject(s) - in vivo , enzyme , potency , bicyclic molecule , chemistry , in vitro , angiotensin converting enzyme , renin–angiotensin system , pharmacology , biochemistry , enzyme inhibitor , stereochemistry , biology , endocrinology , microbiology and biotechnology , blood pressure
Using an earlier model of the favoured orientation of binding functions of angiotensin converting enzyme (ACE) inhibitors, it has been possible to postulate a new, 7,6‐bicyclic system, based on hexahydropyridazine, which might be expected to have high potency. Some members of this system which have been synthesised have been shown to be very active ACE inhibitors, in vitro and in vivo.