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24 R ,25‐Dihydroxyvitamin D stimulates creatine kinase BB activity in chick cartilage cells in culture
Author(s) -
Sömjen Dalia,
Kaye Alvin M.,
Binderman Itzhak
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80143-x
Subject(s) - creatine kinase , cartilage , endocrinology , medicine , aromatase , stimulation , estrogen , uterus , biology , chemistry , microbiology and biotechnology , anatomy , cancer , breast cancer
In chick limb‐bud cartilage cell cultures 24 R ,25‐dihydroxycholecalciferol (24 R ,25(OH) 2 D 3 ), but not 24 S ,25(OH) 2 D 3 , 1α,25(OH) 2 D 3 or 25(OH)D 3 , stimulates the activity of the brain type (BB) isozyme of creatine kinase (EC 2.7.3.2), the ‘estrogen‐induced protein’ first identified in rat uterus. Cultures treated with bromodeoxyuridine, in which cartilage formation in inhibited, show no stimulation of creatine kinase BB by 24 R ,25(OH) 2 D 3 .