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Aldehydic peptides inhibiting renin
Author(s) -
Fehrentz Jean-Alain,
Heitz Annie,
Bertrand Castro,
Cazaubon Catherine,
Nisato Dino
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80141-6
Subject(s) - chemistry , residue (chemistry) , renin–angiotensin system , hydrolysis , peptide bond , amide , renin inhibitor , stereochemistry , transition state analog , peptide , enzyme , biochemistry , combinatorial chemistry , active site , biology , blood pressure , endocrinology
Aldehydic peptides in which the C terminal residue is leucinal or phenylalaninal were synthesized. These compounds exhibited potent inhibition of renin activity and appeared to be precursors of transition state analogues for renin‐catalysed amide bond hydrolysis.