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Complete nucleotide sequence of mouse 18 S rRNA gene: comparison with other available homologs
Author(s) -
Raynal Françoise,
Michot Bernard,
Bachellerie Jean-Pierre
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80139-8
Subject(s) - ribosomal rna , biology , nucleotide , genetics , gene , nucleic acid sequence , homologous chromosome , sequence (biology) , 18s ribosomal rna , conserved sequence , microbiology and biotechnology , base sequence
We present the complete sequence of mouse 18 S rRNA. As indicated by comparison with yeast, Xenopus and rat, the conservation of eukaryotic 18 S rRNA sequences is extensive. However, this conservation is far from being uniform along the molecule: most of the base changes and the size differences between species are concentrated at specific locations. Two distinct classes of divergent traces can be detected which differ markedly in their rates of nucleotide substitution during evolution, and should prove valuable in additional comparative analyses, both for eukaryotic taxonomy and for rRNA higher order organization. Mouse and rat 18 S rRNA sequences differ by only 14 point changes over the 1869 nucleotides of the molecule.