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Biphasic effect of fructose 2,6‐bisphosphate on the liver fructose‐1,6‐bisphosphatase: mechanistic and physiological implications
Author(s) -
Corredor Carlos,
Boscá Lisardo,
Sols Alberto
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80126-x
Subject(s) - fructose 1,6 bisphosphatase , fructose 2,6 bisphosphate , fructose , chemistry , biochemistry , enzyme , glycolysis , phosphofructokinase
Fructose 2,6‐bisphosphate has been claimed to be both a substrate analogue and an allosteric inhibitor of fructose‐1,6‐bisphosphatase. The results reported here show that fructose 2,6‐bisphosphate can be both an inhibitor and an activator of the enzyme, depending on the substrate concentration. This biphasic behaviour at saturating concentrations of substrate can only be due to an allosteric effect. In addition to the mechanistic implication it is possible that this finding may have physiological meaning.