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Adrenergic regulation of ureogenesis in hepatocytes from adrenalectomized rats
Author(s) -
Hernández-Sotomayor S.M.Teresa,
García-Sáinz J.Adolfo
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80118-0
Subject(s) - endocrinology , medicine , epinephrine , extracellular , adrenergic , adrenergic receptor , alpha (finance) , calcium , stimulation , alpha 2 adrenergic receptor , chemistry , biology , receptor , microbiology and biotechnology , construct validity , nursing , patient satisfaction
In hepatocytes from control rats, the ureogenic action of epinephrine is mainly mediated through α 1 ‐adrenoceptors and the effect is independent of the presence of extracellular calcium. In hepatocytes from adrenalectomized rats, both α 1 ‐ and β‐adrenoceptors are involved in the action of epinephrine. Furthermore, the α 1 ‐adrenergic‐mediated stimulation of ureogenesis in these cells is dependent on the presence of extracellular calcium. Our results indicate that glucocorticoids modulate the calcium dependency of α 1 ‐adrenergic effects and are consistent with our suggestion that two pathways are involved in the transduction of the α 1 ‐adrenergic signal.