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Amino acid sequence of human factor D of the complement system
Author(s) -
Johnson D.M.A.,
Gag J.,
Reid K.B.M.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80110-6
Subject(s) - trypsin , serine , proteases , biochemistry , peptide sequence , cyanogen bromide , serine protease , complement factor i , amino acid , chymotrypsin , complement factor b , factor h , masp1 , elastase , chemistry , complement system , biology , protease , enzyme , antibody , genetics , gene
The amino acid sequence of human factor D is proposed from the analysis of the peptides produced by treatment of the factor D with cyanogen bromide, iodosobenzoic acid, trypsin and V‐8 protease. Comparison of the proposed sequence with the sequences of other serine esterases indicated that factor D, although it is a plasma serine esterase, is more closely related to certain proteases not found in the plasma than to other plasma serine esterases of the complement system. For example, 36% and 32% identity in amino acid sequence was found on comparison of factor D with elastase and group‐specific protease, respectively. Whereas only 27% and 18% identity was observed between factor D and the other complement serine esterases, Clr and factor B, respectively.