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Stability of 2′ – 5′)oligoriboadenylates in various sera
Author(s) -
Vilček Š.,
Vrtiak O.J.,
Smrt J.,
Jurovčík M.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80102-7
Subject(s) - chemistry
Avian and mammalian sera were found to contain an enzyme activity degrading 2–5A oligonucleotides. The most extensive degradation of the A2′p5′ A was observed in chicken serum. Degradation of this compound is not affected by the presence of cAMP, dsRNA, Mg 2+ , but is significantly inhibited by EDTA. The enzyme activity described is not inactivated by heating to 56°C for 30 min. The 5‐mU3′p5′ A has also been degraded in chicken serum