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Evidence that helodermin, a newly extracted peptide from Gila monster venom, is a member of the secretin/VIP/PHI family of peptides with an original pattern of biological properties
Author(s) -
Robberecht Patrick,
Waelbroeck Magali,
Dehaye Jean-Paul,
Winand Jacques,
Vandermeers André,
Vandermeers-Piret Marie-Claire,
Christophe Jean
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80095-2
Subject(s) - secretin , secretin family , adenylate kinase , venom , cyclase , peptide , vasoactive intestinal peptide , neuropeptide , biology , membrane , chemistry , biochemistry , medicine , endocrinology , pancreas , enzyme , receptor
Helodermin, a newly isolated peptide from the venom of Gila monster ( Heloderma suspectum ) was shown to stimulate the adenylate cyclase activity of rat pancreatic membranes as effectively as secretin and VIP. It also increased cyclic AMP levels and inhibited [ 125 I]VIP binding in rat pancreatic acini. Finally, helodermin activated adenylate cyclase in membranes from rat heart, rat brain, and human heart, showing properties analogous yet distinct from those of secretin, VIP and PHI.