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Regulation of 2′,5′‐oligo(A) synthetase activity in theophylline‐treated NIH 3T3 cells
Author(s) -
Itkes A.V.,
Turpaev K.T.,
Kartasheva O.N.,
Tunitskaya V.L.,
Kafiani C.A.,
Severin E.S.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80072-1
Subject(s) - theophylline , 3t3 cells , chemistry , biochemistry , pharmacology , biology , transfection , gene
Sequential treatment of NIH 3T3 cells with theophylline and actinomycin D results in an enhancement of 2′,5′‐oligo(A) synthetase activity 2–3‐fold exceeding that induced by treatment with theophylline only. This ‘superinduction’ phenomenon suggests the existence of a negative control of the enzyme that involves a labile, transcription‐dependent factor.