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The sarcoplasmic reticulum calcium pump
Author(s) -
Tanford Charles
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80033-2
Subject(s) - endoplasmic reticulum , calcium , chemistry , biophysics , biochemistry , biology , organic chemistry
Free energy transduction in active transport resembles other protein‐catalyzed processes, occurring by an ordered sequence of discrete bond‐breaking and bond‐making steps. The bonds that affect the transported ion directly are chelation bonds, which after the chemical potential of the bound ion, but not its chemical identity. Available data for the sarcoplasmic reticulum Ca pump (admittedly incomplete) suggest that more than 50% of the free energy transfer may be localized to a single step of the reaction cycle.