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Interaction of synthetic signal sequence fragments with model membranes
Author(s) -
Nagaraj R.
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80018-6
Subject(s) - liposome , peptide , chemistry , lysozyme , sequence (biology) , fluorescence anisotropy , fluorescence , membrane , signal peptide , bilayer , biophysics , peptide sequence , combinatorial chemistry , biochemistry , biology , physics , quantum mechanics , gene
Peptide fragments corresponding to the signal sequence of chicken lysozyme, labelled with the fluorescent 5‐dimethylaminoaphthalene‐1‐sulfonyl(dansyl) group have been synthesized. The emission characteristics and fluorescence polarization of the dansyl group have been used to study the interaction of signal sequence fragments with liposomes. The peptide fragments bind to liposomes and are associated with the hydrophobic core of the bilayer.