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Synthesis of the nuclear protein cyclin in growing, senescent and morphologically transformed human skin fibroblasts
Author(s) -
Celis Julio E.,
Bravo Rodrigo
Publication year - 1984
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(84)80006-x
Subject(s) - human skin , biology , microbiology and biotechnology , cyclin , fibroblast , nuclear protein , cell growth , cyclin d , cell , cell cycle , cell culture , biochemistry , genetics , gene , transcription factor
Quantitative two‐dimensional gel electrophoretic analysis (IEF) of the nuclear polypeptide cyclin in normal human skin biopsies, growing and senescent fibroblasts and morphologically transformed skin fibroblasts (limited life span) has revealed a direct correlation between the levels of this protein and the proliferative state of the cells. These results strengthen the notion that cyclin may be a key component of the pathway(s) that control cell proliferation.