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The production of hydroxyl radicals by adriamycin in red blood cells
Author(s) -
Bannister J.V.,
Thornalley P.J.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)81139-9
Subject(s) - radical , chemistry , hydrogen peroxide , spin trapping , hydroxyl radical , photochemistry , adduct , hemoglobin , mannitol , semiquinone , biochemistry , organic chemistry , redox
Spin trapping of the free radicals formed from the interaction between adriamycin and red blood cells resulted in the formation of a hydroxyl spin adduct. The formation of hydroxyl radicals was found to be inhibited by mannitol. Hemoglobin was found not to be obligatory for the formation of hydroxyl radicals which probably result from the reduction of hydrogen peroxide by adriamycin semiquinone.